Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition

Written By Melissa Davis

This work shows that gene screening can be done in patient-derived tumor models and can point to possible drug combinations. The results are an early research finding; further studies are needed before they could guide treatment for patients.

Melissa Davis https://www.mbdavislab.org
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Tumor-Associated Lymphocytes and Breast Cancer Survival in Black and White Women
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Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis